Health Systems 20/20 (HS 20/20), was a five-year (2006-2011) cooperative agreement, funded by the U.S. Agency for International Development (USAID). It offered help to the USAID-supported countries in solving problems in health governance, finance, operations, and capacity building. By working on these dimensions of strengthening health systems, the project helped people in developing countries, to gain access to the population, health, and nutrition (PHN) services.

Health financing,  governance and operations initiatives were integrated in Health System 20/20. This integrated approach was focused on building capacity for long-term sustainability of system strengthening efforts. The project acted through global leadership, technical assistance, brokering and grant making, research, professional networking, and information dissemination.